Design and Analysis of Pragmatic Trials (Chapman & Hall/CRC Biostatistics Series) (Original PDF from Publisher)

Design and Analysis of Pragmatic Trials (Chapman & Hall/CRC Biostatistics Series) (Original PDF from Publisher)

Via Song Zhang , Chul Ahn and Hong Zhu

This book starts with an overview of pragmatic cluster randomized trials (PCTs) and examines a number of pragmatic issues that statisticians must take into consideration throughout the design phase .

It contains sample size calculations , sensitivity analyses and examples for sample size computation in addition to discussing the benefits and drawbacks of each type of PCT . The sample size formulae for various outcomes from the exponential family , including continuous , binary and count variables , will be derived using the generalized estimating equation (GEE) method .

Cluster randomized designs , matched-pair cluster randomized designs , stratified cluster randomized designs , stepped-wedge cluster randomized designs , longitudinal cluster randomized designs and crossover cluster randomized designs are some of the experimental designs that have been frequently used in PCTs . It highlights how adaptable the GEE approach is to practical problems like hierarchical correlation structures , various patterns of missing data, randomly fluctuating cluster sizes , etc . According to reports, the GEE technique results in under-estimated variation with few clusters .

For the design of PCTs, the fix for this issue is being looked into . By outlining the benefits and drawbacks of various PCTs and offering sample size formulas that address a range of practical concerns , this book can help practitioners in the design of PCTs and facilitate the effective implementation of PCTs to enhance healthcare . It can also be used as a textbook for graduate-level biostatistics students to improve their understanding of or proficiency with clinical trial design .

Important characteristics : Include sample size formulae , sensitivity analyses and examples while discussing the benefits and drawbacks of each type of PCT . fill a need in the market for instruction manuals on PCT sample size computation ; There are numerous experimental designs used by PCTs covered ; Due to the accommodation of frequent pragmatic concerns encountered in real-world practice , sample size solutions can be quickly implemented ; useful for biostatisticians working on clinical trial design in academia and industry ; For graduate students specializing in statistics and biostatistics, it can serve as a textbook .

Design and Analysis of Pragmatic Trials (Chapman & Hall/CRC Biostatistics Series) (Original PDF from Publisher)

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